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A CASE OF RECURRENT MULTIPLE SKIN ERUPTIONS
A 23 year old lady,Psychologist by Occupation, resident of Nalgonda Came to the OPD with
Chief complaints of - Multiple small Painful red colored skin eruptions over the upper and lower limbs and back of the trunk since 8 months
History of presenting illness
Patient was apparently asymptomatic 8 months ago and then she developed multiple small red Palpable eruptions on both lower limbs which were not associated with Burning or itching sensation . After 1 week She developed Occasional Burning over the lesions. She consulted a local dermatologist where she was prescribed antihistamines and was asked to avoid oily foods and vit. C and the lesions didn't subside. So she was referred to another Hospital where she was diagnosed with HENOCH SCHONLEIN PURPURA
Investigations done were - CUE, ASO TITRE, ESR, RFT, Serum Bilirubin which were normal.
Diascopy showed Non blanchable palpable erythematous Purpura
Medications -
- Antihistaminics[Tab. TECZINE 5 mg]
- Calosoft lotion
- Halovate lotion
After 1 week new purpuric lesion started to develop Over the thighs
Investigations : Serum Creatinine and Uric acid were normal
Medications
- OMNACORTIL 20mg
- PANTOP 40 Mg
After 2 Weeks she had history of travel for 3 days during which she developed
painful Soles
On the next day She presented with increased number of purpuric lesions over both the legs and hands and back of the trunk associated with pain, itching and Burning Sensation
H/o Joint pains initially in the left wrist later Progressed to left elbow
She had Pedal edema and Pain in the lower limb
Investigations -
Haemogram showed normochromic normocytic Blood Picture with Neutrophilic leucocytosis
Medications - Tab. ZERODOL and Tab. SHELCAL
After a week She presented with Weight gain of 5kgs in a week and Facial Puffiness. On Examination, Striae were Seen on legs and thighs and few purpura located Over thighs, legs and dorsum of Hand
Advised to Consider using immunosuppressants and taper steroids.
Steroid dose was reduced from 20 mg to 15 mg
Tab. METHOTREXATE 2.5 mg test dose was given
Tab.FOLIC ACID 5mg on a day other than Methotrexate
After 10 days She complained abdominal pain which improved by next morning and Methotrexate dose was increased to 7.5 mg and FUDIC CREAM Was prescribed
On follow up after a week She was found to tolerate the dose of Methotrexate well with reduction in number of new lesions and the above drugs were continued with addition of MOISTUREX Soft cream
4 days later improvement was Seen with mild pain on both the soles (reduced in intensity)
- Methotrexate dose was increased to 10 mg
- folic acid on the day other than Methotrexate
- Tab. ZERODOL P(SOS)
- Tab. MVT
on follow up after a week Improvement was seen with a Cummulative dose of 30 mg and She Complained of mild itching and Burning Sensation over pubic region
On Examination Single Hyperpigmented plaque noted over Pubic area which aggravated on Using Sanitary Napkins and was prescribed LULIFIN cream
4 days later improvement was Seen with Cumulative dose of Methotrexate 50 mg and following drugs were Prescribed
- LIVOGEN on day other than Methotrexate
- Methotrexate12.5 mg
- Tab. SUPRADYNE
- ABZORB Dusting Powder
2 Weeks later improvement was seen
Cumulative dose of Methotrexate75 mg and the above medications were continued and 1 week later She Complained of Nausea, loss of appetite and Insomnia and she was Prescribed Tab. Amitriptyline 5 mg
2 weeks later She Showed Painful skin lesions on both palms and Soles with Cumulative dose of Methotrexate 125 mg
Medications
- METHOTREXATE 12.5 mg
- VENUSIA Soft lotion on itchy lesions
- NMFE lotion over stretch marks and all over the body
- Tab. LIVOGEN on day other than Methotrexate
- Tab. SUPRADYNE
2 Weeks later She presented with new lesions over Palms associated with itching (Cumulative dose of Methotrexate 150 mg) and Tab. TECZINE 10 mg and Tab. PANTOP-D were prescribed
20 days later She presented with new lesions Over Palms and soles and between the Web Spaces Since 1 week and painful Soles while walking especially early in the morning
On examination Multiple erythematous pinpoint Sized Papules noted all over the palms,Web Spaces and both Soles ( Cumulative dose of Methotrexate 170 mg )
Medications
- Methotrexate dose reduced to 5 mg Once weekly for 2 Weeks and then 2.5 mg Weekly once for1 week
- NOMATE Cream on alternate days over the lesions
- Liquid PARAFFIN
10 days later She complained of appearance of new lesions and was advised to Stop all medications and report to OPD for Skin biopsy and was prescribed Tab.DEFZA 12 mg and Tab. TECZINE 5 mg (for pain)
- 2 weeks later, Biopsy was done and Histopathological report showed Neutrophilic Leucocytoclastic Vasculitis and was advised to check G6PD levels and was prescribed Tab. DAPSONE 50mg
20 days later She presented with Itchy purpura Over both feet
Medications given were
- Tab.TAXIM-O 100 mg
- Tab. ASCARZIN
- Tab. EVION 400 mg
- Tab. DAPSONE 50 mg
- ATARAX anti itch lotion
15 days later She complained of new lesions
Investigations -
- Haemogram [ Hb-11.6 g /dl, PCV-33.7 vol% , RBC-3.7 mil/mm³]
- Peripheral Smear [normochromic normocytic RBC with WBC in normal limits]
- D-Dimer [elevated]
- Prothrombin time[14 sec]
- APTT [28 sec]
No H/o hematuria,hematemesis and epistaxis
Past history -
No History of similar complaints in the past, she is not a k/c/o diabetes mellitus, hypertension, epilepsy, tuberculosis, asthma.
Family history -
No similar complaints in the family
Personal history -
Mixed diet
Normal appetite
Adequate sleep
Bowel and bladder movements- regular
No addictions and No known drug allergies
General physical Examination
Patient is conscious, coherent,cooperative and moderately built and moderately nourished
Vitals
→ patient is afebrile
→ BP-110/80 mm Hg
→ PR-70 bpm
→ RR-16 Cpm
✓SpO2- 98%
✓GRBS - 122gm/dl
→ NO Pallor, Icterus, Cyanosis, clubbing, Odema, lymphadenopathy.
Local Examination -
RED erythematous lesions Over Hands, legs, Palms and Soles including Web Spaces
CNS Examination
- Higher mental functions-normal
- Cranial nerves- intact
- Sensory system- normal
- Motor system- normal
- Meningeal signs- absent
- Cerebellar signs- absent
CVS Examination
S1 and S2 heard , No murmurs heard
Respiratory system examination
Normal Vesicular Breath sounds heard
No added sounds
Abdominal examination
Inspection-
Shape : elliptical
Umbilicus - central and inverted
No scars , sinuses or engorged veins
Palpation:No tenderness , No organomegaly
Percussion: Tympanic
Auscultation: Normal
Investigations reports:
PROVISIONAL DIAGNOSIS - HENOCH SCHONLEIN PURPURA
Treatment
Patient is on medications
- Tab. Dapsone 100mg
- Syrup orofer 5ml
- Tab. Shelcal
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